VEGF-C/Flt-4 axis in tumor cells contributes to the progression of oral squamous cell carcinoma via upregulating VEGF-C itself and contactin-1 in an autocrine manner

Tumor cell-derived vascular endothelial growth factor (VEGF)-C has been primarily implicated in promoting lymphangiogenesis by activating Flt-4 (VEGFR-3) expressed on lymphatic endothelial cells via a paracrine mechanism. Flt4 has also been shown to be expressed selectively in subsets of cancer cell...

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Publicado en:Am J Cancer Res
Autores principales: Shigetomi, Seiji, Imanishi, Yorihisa, Shibata, Katsushi, Sakai, Nobuya, Sakamoto, Koji, Fujii, Ryoichi, Habu, Noboru, Otsuka, Kuninori, Sato, Yoichiro, Watanabe, Yoshihiro, Shimoda, Masayuki, Kameyama, Kaori, Ozawa, Hiroyuki, Tomita, Toshiki, Ogawa, Kaoru
Formato: Artigo
Lenguaje:Inglês
Publicado: e-Century Publishing Corporation 2018
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220132/
https://ncbi.nlm.nih.gov/pubmed/30416855
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