Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

BACKGROUND: The epithelial-to-mesenchymal transition (EMT) accompanied by the downregulation of E-cadherin has been thought to promote metastasis. Cyclooxygenase-2 (Cox-2) is presumed to contribute to cancer progression through its multifaceted function, and recently its inverse relationship with E-...

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Détails bibliographiques
Auteurs principaux: Fujii, Ryoichi, Imanishi, Yorihisa, Shibata, Katsushi, Sakai, Nobuya, Sakamoto, Koji, Shigetomi, Seiji, Habu, Noboru, Otsuka, Kuninori, Sato, Yoichiro, Watanabe, Yoshihiro, Ozawa, Hiroyuki, Tomita, Toshiki, Kameyama, Kaori, Fujii, Masato, Ogawa, Kaoru
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030015/
https://ncbi.nlm.nih.gov/pubmed/24887090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-33-40
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