Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1–mediated endocytosis

Matrix protease activity is fundamental to developmental tissue patterning and remains influential in adult homeostasis. In cartilage, the principal matrix proteoglycan is aggrecan, the protease-mediated catabolism of which defines arthritis; however, the pathophysiologic mechanisms that drive aberr...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Coveney, Clarissa R., Collins, Isabella, Mc Fie, Megan, Chanalaris, Anastasios, Yamamoto, Kazuhiro, Wann, Angus K. T.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219823/
https://ncbi.nlm.nih.gov/pubmed/29920219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800334
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