Miransertib (ARQ 092), an orally-available, selective Akt inhibitor is effective against Leishmania

Leishmaniasis is amongst the most important neglected diseases, afflicting more than 12 million people in 88 countries. There is an urgent need for safe orally bioavailable and cost-effective drugs for the treatment of leishmaniasis. It has recently been shown that Leishmania activates host macropha...

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Bibliographic Details
Published in:PLoS One
Main Authors: Nandan, Devki, Zhang, Naixin, Yu, Yi, Schwartz, Brian, Chen, Stella, Kima, Peter E., Reiner, Neil E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219794/
https://ncbi.nlm.nih.gov/pubmed/30399177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206920
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