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In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy

Noonan Syndrome with Multiple Lentigines (NSML, formerly LEOPARD syndrome) is an autosomal dominant "RASopathy" disorder manifesting in congenital heart disease. Most cases of NSML are caused by catalytically inactivating mutations in the protein tyrosine phosphatase (PTP), non-receptor ty...

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Опубликовано в: :PLoS One
Главные авторы: Wang, Jianxun, Chandrasekhar, Vasanth, Abbadessa, Giovanni, Yu, Yi, Schwartz, Brian, Kontaridis, Maria I.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459472/
https://ncbi.nlm.nih.gov/pubmed/28582432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178905
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