In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy

Noonan Syndrome with Multiple Lentigines (NSML, formerly LEOPARD syndrome) is an autosomal dominant "RASopathy" disorder manifesting in congenital heart disease. Most cases of NSML are caused by catalytically inactivating mutations in the protein tyrosine phosphatase (PTP), non-receptor ty...

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Bibliographic Details
Published in:PLoS One
Main Authors: Wang, Jianxun, Chandrasekhar, Vasanth, Abbadessa, Giovanni, Yu, Yi, Schwartz, Brian, Kontaridis, Maria I.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459472/
https://ncbi.nlm.nih.gov/pubmed/28582432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178905
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