ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

A coding variant of the inflammatory bowel disease (IBD) risk gene ATG16L1 has been associated with defective autophagy and deregulation of endoplasmic reticulum (ER) function. IL-22 is a barrier protective cytokine by inducing regeneration and antimicrobial responses in the intestinal mucosa. We sh...

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Detalhes bibliográficos
Publicado no:J Exp Med
Principais autores: Aden, Konrad, Tran, Florian, Ito, Go, Sheibani-Tezerji, Raheleh, Lipinski, Simone, Kuiper, Jan W., Tschurtschenthaler, Markus, Saveljeva, Svetlana, Bhattacharyya, Joya, Häsler, Robert, Bartsch, Kareen, Luzius, Anne, Jentzsch, Marlene, Falk-Paulsen, Maren, Stengel, Stephanie T., Welz, Lina, Schwarzer, Robin, Rabe, Björn, Barchet, Winfried, Krautwald, Stefan, Hartmann, Gunther, Pasparakis, Manolis, Blumberg, Richard S., Schreiber, Stefan, Kaser, Arthur, Rosenstiel, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219748/
https://ncbi.nlm.nih.gov/pubmed/30254094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171029
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