Comprehensive Ara-C SNP score predicts leukemic cell intracellular ara-CTP levels in pediatric acute myeloid leukemia patients

AIM: Cytarabine (Ara-C), a mainstay of acute myeloid leukemia (AML) treatment, is a prodrug requiring activation to ara-CTP for its antileukemic activity. Aim of this study was to evaluate impact of genetic variants in the key genes involved in ara-C metabolism on the leukemic cell intracellular lev...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Pharmacogenomics
Asıl Yazarlar: Elsayed, Abdelrahman H, Cao, Xueyuan, Crews, Kristine R, Gandhi, Varsha, Plunkett, William, Rubnitz, Jeffrey E, Ribeiro, Raul C, Pounds, Stanley B, Lamba, Jatinder K
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Future Medicine Ltd 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219441/
https://ncbi.nlm.nih.gov/pubmed/30088438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2018-0086
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