Comprehensive Ara-C SNP score predicts leukemic cell intracellular ara-CTP levels in pediatric acute myeloid leukemia patients

AIM: Cytarabine (Ara-C), a mainstay of acute myeloid leukemia (AML) treatment, is a prodrug requiring activation to ara-CTP for its antileukemic activity. Aim of this study was to evaluate impact of genetic variants in the key genes involved in ara-C metabolism on the leukemic cell intracellular lev...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Pharmacogenomics
Autors principals: Elsayed, Abdelrahman H, Cao, Xueyuan, Crews, Kristine R, Gandhi, Varsha, Plunkett, William, Rubnitz, Jeffrey E, Ribeiro, Raul C, Pounds, Stanley B, Lamba, Jatinder K
Format: Artigo
Idioma:Inglês
Publicat: Future Medicine Ltd 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219441/
https://ncbi.nlm.nih.gov/pubmed/30088438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2018-0086
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars