RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients

BACKGROUND: Ribonucleotide reductase catalyzes an essential step in the cellular production of deoxyribonucleotide triphosphates and has been associated with clinical outcome in cancer patients receiving nucleoside analog-based chemotherapy. MATERIALS & METHODS: In the current study, we sequence...

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Autori principali: Cao, Xueyuan, Mitra, Amit K, Pounds, Stanley, Crews, Kristine R, Gandhi, Varsha, Plunkett, William, Dolan, M Eileen, Hartford, Christine, Raimondi, Susana, Campana, Dario, Downing, James, Rubnitz, Jeffrey E, Ribeiro, Raul C, Lamba, Jatinder K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3860742/
https://ncbi.nlm.nih.gov/pubmed/24024897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.13.131
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