Genetic Variants in Cytosolic 5′-Nucleotidase II Are Associated with Its Expression and Cytarabine Sensitivity in HapMap Cell Lines and in Patients with Acute Myeloid Leukemia

Cytosolic 5′-nucleotidase II (NT5C2) is involved in the development of 1-β-d-arabinofuranosylcytosine (ara-C) resistance and has been associated with clinical outcome in patients receiving ara-C-based chemotherapy. NT5C2 inactivates ara-C by dephosphorylating ara-C monophosphate to ara-C. In this st...

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Detalhes bibliográficos
Main Authors: Mitra, Amit K., Crews, Kristine R., Pounds, Stanley, Cao, Xueyuan, Feldberg, Tanya, Ghodke, Yogita, Gandhi, Varsha, Plunkett, William, Dolan, M. Eileen, Hartford, Christine, Raimondi, Susana, Campana, Dario, Downing, James, Rubnitz, Jeffrey E., Ribeiro, Raul C., Lamba, Jatinder K.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186292/
https://ncbi.nlm.nih.gov/pubmed/21712425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.182873
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