Genetic Variants in Cytosolic 5′-Nucleotidase II Are Associated with Its Expression and Cytarabine Sensitivity in HapMap Cell Lines and in Patients with Acute Myeloid Leukemia

Cytosolic 5′-nucleotidase II (NT5C2) is involved in the development of 1-β-d-arabinofuranosylcytosine (ara-C) resistance and has been associated with clinical outcome in patients receiving ara-C-based chemotherapy. NT5C2 inactivates ara-C by dephosphorylating ara-C monophosphate to ara-C. In this st...

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Hlavní autoři: Mitra, Amit K., Crews, Kristine R., Pounds, Stanley, Cao, Xueyuan, Feldberg, Tanya, Ghodke, Yogita, Gandhi, Varsha, Plunkett, William, Dolan, M. Eileen, Hartford, Christine, Raimondi, Susana, Campana, Dario, Downing, James, Rubnitz, Jeffrey E., Ribeiro, Raul C., Lamba, Jatinder K.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2011
Témata:
Metabolism, Transport, and Pharmacogenomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186292/
https://ncbi.nlm.nih.gov/pubmed/21712425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.182873
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