VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for multi-drug resistance (MDR). VS-4718, a tyrosine kinase inhibitor targeting focal adhesion kinase (FAK) with a potential anticancer effect, is currently evaluated in clinical trials. In...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Ji, Ning, Yang, Yuqi, Cai, Chao-Yun, Lei, Zi-Ning, Wang, Jing-Quan, Gupta, Pranav, Teng, Qiu-Xu, Chen, Zhe-Sheng, Kong, Dexin, Yang, Dong-Hua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218957/
https://ncbi.nlm.nih.gov/pubmed/30425643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01236
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge