SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

BACKGROUND: We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibr...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Wei, Chengguo, Banu, Khadija, Garzon, Felipe, Basgen, John M., Philippe, Nimrod, Yi, Zhengzi, Liu, Ruijie, Choudhuri, Jui, Fribourg, Miguel, Liu, Tong, Cumpelik, Arun, Wong, Jenny, Khan, Mubeen, Das, Bhaskar, Keung, Karen, Salem, Fadi, Campbell, Kirk N., Kaufman, Lewis, Cravedi, Paolo, Zhang, Weijia, O'Connell, Philip J., He, John Cijiang, Murphy, Barbara, Menon, Madhav C.
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2018
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218856/
https://ncbi.nlm.nih.gov/pubmed/30341149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018060573
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