Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis

Fibrosis underlies the loss of renal function in patients with chronic kidney disease (CKD) and in kidney transplant recipients with chronic allograft nephropathy (CAN). Here, we studied the effect of an intronic SNP in SHROOM3, which has previously been linked to CKD, on the development of CAN in a...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Menon, Madhav C., Chuang, Peter Y., Li, Zhengzhe, Wei, Chengguo, Zhang, Weijia, Luan, Yi, Yi, Zhengzi, Xiong, Huabao, Woytovich, Christopher, Greene, Ilana, Overbey, Jessica, Rosales, Ivy, Bagiella, Emilia, Chen, Rong, Ma, Meng, Li, Li, Ding, Wei, Djamali, Arjang, Saminego, Millagros, O’Connell, Philip J., Gallon, Lorenzo, Colvin, Robert, Schroppel, Bernd, He, John Cijiang, Murphy, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382250/
https://ncbi.nlm.nih.gov/pubmed/25437874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76902
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