Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis

Fibrosis underlies the loss of renal function in patients with chronic kidney disease (CKD) and in kidney transplant recipients with chronic allograft nephropathy (CAN). Here, we studied the effect of an intronic SNP in SHROOM3, which has previously been linked to CKD, on the development of CAN in a...

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Publicat a:J Clin Invest
Autors principals: Menon, Madhav C., Chuang, Peter Y., Li, Zhengzhe, Wei, Chengguo, Zhang, Weijia, Luan, Yi, Yi, Zhengzi, Xiong, Huabao, Woytovich, Christopher, Greene, Ilana, Overbey, Jessica, Rosales, Ivy, Bagiella, Emilia, Chen, Rong, Ma, Meng, Li, Li, Ding, Wei, Djamali, Arjang, Saminego, Millagros, O’Connell, Philip J., Gallon, Lorenzo, Colvin, Robert, Schroppel, Bernd, He, John Cijiang, Murphy, Barbara
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382250/
https://ncbi.nlm.nih.gov/pubmed/25437874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76902
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