SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

BACKGROUND: We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibr...

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Publicado en:J Am Soc Nephrol
Autores principales: Wei, Chengguo, Banu, Khadija, Garzon, Felipe, Basgen, John M., Philippe, Nimrod, Yi, Zhengzi, Liu, Ruijie, Choudhuri, Jui, Fribourg, Miguel, Liu, Tong, Cumpelik, Arun, Wong, Jenny, Khan, Mubeen, Das, Bhaskar, Keung, Karen, Salem, Fadi, Campbell, Kirk N., Kaufman, Lewis, Cravedi, Paolo, Zhang, Weijia, O'Connell, Philip J., He, John Cijiang, Murphy, Barbara, Menon, Madhav C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2018
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218856/
https://ncbi.nlm.nih.gov/pubmed/30341149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018060573
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