SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

BACKGROUND: We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibr...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Wei, Chengguo, Banu, Khadija, Garzon, Felipe, Basgen, John M., Philippe, Nimrod, Yi, Zhengzi, Liu, Ruijie, Choudhuri, Jui, Fribourg, Miguel, Liu, Tong, Cumpelik, Arun, Wong, Jenny, Khan, Mubeen, Das, Bhaskar, Keung, Karen, Salem, Fadi, Campbell, Kirk N., Kaufman, Lewis, Cravedi, Paolo, Zhang, Weijia, O'Connell, Philip J., He, John Cijiang, Murphy, Barbara, Menon, Madhav C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2018
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218856/
https://ncbi.nlm.nih.gov/pubmed/30341149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018060573
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