SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

BACKGROUND: We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibr...

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Библиографические подробности
Опубликовано в: :J Am Soc Nephrol
Главные авторы: Wei, Chengguo, Banu, Khadija, Garzon, Felipe, Basgen, John M., Philippe, Nimrod, Yi, Zhengzi, Liu, Ruijie, Choudhuri, Jui, Fribourg, Miguel, Liu, Tong, Cumpelik, Arun, Wong, Jenny, Khan, Mubeen, Das, Bhaskar, Keung, Karen, Salem, Fadi, Campbell, Kirk N., Kaufman, Lewis, Cravedi, Paolo, Zhang, Weijia, O'Connell, Philip J., He, John Cijiang, Murphy, Barbara, Menon, Madhav C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Nephrology 2018
Предметы:
Basic Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218856/
https://ncbi.nlm.nih.gov/pubmed/30341149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018060573
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