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Deficient Wnt Signaling and Synaptic Vulnerability in Alzheimer’s Disease: Emerging Roles for the LRP6 Receptor

Synapse dysfunction and loss represent critical early events in the pathophysiology of Alzheimer’s disease (AD). While extensive research has elucidated the direct synaptotoxic effects of Amyloid-β (Aβ) oligomers, less is known about how signaling pathways at the synapse are affected by Aβ. A better...

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Detalhes bibliográficos
Publicado no:Front Synaptic Neurosci
Main Authors: Buechler, Johanna, Salinas, Patricia C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218458/
https://ncbi.nlm.nih.gov/pubmed/30425633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnsyn.2018.00038
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