Deficiency in LRP6-mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease

Alzheimer’s disease (AD) is an age-related neurological disorder characterized by synaptic loss and dementia. The low-density lipoprotein receptor-related protein 6 (LRP6) is an essential co-receptor for Wnt signaling and its genetic variants have been linked to AD risk. Here we report that neuronal...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Chia-Chen, Tsai, Chih-Wei, Deak, Ferenc, Rogers, Justin, Penuliar, Michael, Sung, You Me, Maher, James Nicholas, Fu, Yuan, Li, Xia, Xu, Huaxi, Estus, Steven, Hoe, Hyang-Sook, Fryer, John D., Kanekiyo, Takahisa, Bu, Guojun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199382/
https://ncbi.nlm.nih.gov/pubmed/25242217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.08.048
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