PDTM-34. TARGETING H3.3G34R/V RE-WIRING OF THE EPIGENOME IN PAEDIATRIC GLIOBLASTOMA OF CHILDREN AND YOUNG ADULTS

Around 15% of cerebral hemispheric glioblastomas (GBM) of children and young adults harbour G34R/V mutations in H3F3A, encoding the histone H3.3 variant. These tumours have a peak incidence in late adolescence but are found up to 30yrs of age, and have conflicting data as to their prognosis compared...

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Publié dans:Neuro Oncol
Auteurs principaux: Bjerke, Lynn, Mackay, Alan, Carvalho, Diana, Pemberton, Helen, Molinari, Valeria, Vinci, Maria, Carceller, Fernando, Marshall, Lynley, Moore, Andrew, Montero Carcaboso, Angel, Lord, Chris, Hargrave, Darren, Jones, Chris
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217707/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.874
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