PDTM-31. DRUG SCREENING LINKED TO MOLECULAR PROFILING IDENTIFIES NOVEL DEPENDENCIES IN PATIENT-DERIVED PRIMARY CULTURES OF PAEDIATRIC HIGH GRADE GLIOMA AND DIPG

Paediatric high grade glioma and diffuse midline glioma (including DIPG) are comprised of multiple biological and clinical subgroups, the majority of which urgently require novel therapies. Patient-derived in vitro primary cell cultures represent potentially useful tools for mechanistic and preclini...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Mackay, Alan, Carvalho, Diana, Molinari, Valeria, Pemberton, Helen, Temelso, Sara, Burford, Anna, Clarke, Matthew, Fofana, Mariama, Boult, Jessica, Izquierdo, Elisa, Taylor, Katy, Bjerke, Lynn, Fazal Salom, Janat, Kessler, Ketty, Rogers, Rebecca, Marshall, Lynley, Carceller, Fernando, Pears, Jane, Moore, Andrew, Miele, Evelina, Carai, Andrea, Mastronuzzi, Angela, Robinson, Simon, Lord, Chris, Olaciregui, Nagore, Mora, Jaume, Montero Carcaboso, Angel, Hargrave, Darren, Vinci, Maria, Jones, Chris
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217673/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.871
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