PDTM-12. DLX2 TRANSCRIPTIONAL REGULATION OF CENTRAL NERVOUS SYSTEM CELL FATE RELEVANCE TO PEDIATRIC DIFFUSE MIDLINE GLIOMAS WITH HISTONE 3 MUTATIONS

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is refractory to current therapy with less than 2% long term survivors. The identification of histone H3.1/H3.3 K27M mutations in most DIPG has provided new insights into the biology of this fatal disease. The DLX homeobox genes are expressed in...

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Published in:Neuro Oncol
Main Authors: Nevin, Mikaela, Song, Xiaohua, Becher, Oren, Underhill, D Alan, Godbout, Roseline, Eisenstat, David
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217625/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.854
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