DIPG-11. TRANSCRIPTIONAL REGULATION OF NEURAL PROGENITOR CELL FATE BY DLX HOMEOBOX GENES - RELEVANCE TO DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

DIPG is refractory to current therapies. The identification of histone H3.1/H3.3 K27M mutations in most DIPG has provided novel insights. DLX (distal-less) genes are expressed in the developing forebrain. The Dlx1/Dlx2 double knockout (DKO) mouse (dies at P0) has loss of tangential GABAergic interne...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Eisenstat, David, Zagozewski, Jamie, Japoni, Sara, Song, Xiaohua, Godbout, Roseline, Underhill, Alan, Becher, Oren
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012488/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.104
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