TRANSCRIPTIONAL REGULATION OF OLIGODENDROGLIAL CELL FATE BY DLX HOMEOBOX GENES: POTENTIAL RELEVANCE TO HISTONE H3.3 MUTATIONS IN PEDIATRIC HIGH GRADE GLIOMA

BACKGROUND: The discovery of variant histone H3.3 somatic driver mutations in pediatric high grade gliomas (pHGG) has provided important insights into their pathogenesis. The K27M and G34V/R mutants are usually localized to different neuroanatomic compartments (deep midline/brainstem or superficial/...

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Main Authors: Eisenstat, David D., Zagozewski, Jamie, Ziegler, Kirby, Japoni, Sara, Jiang, Qiang, Underhill, D. Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144554/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.10
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