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MEDU-50. TRANSCRIPTIONAL REGULATION OF THE HOMEOBOX GENES CRX AND OTX2 - IMPLICATIONS FOR MEDULLOBLASTOMA GROUP 3

BACKGROUND: Generation of disease-specific models and development of new treatments for non-WNT/non-SHH medulloblastomas (MB) is an urgent need. Group 3 MB is characterized by amplifications of MYC and/or OTX2. Furthermore, transcriptional profiling of group 3 MB shows dysregulation of GABAergic and...

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Publicado en:Neuro Oncol
Autores principales: Hejazi, Maryam, Zagozewski, Jamie, Eisenstat, David
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475170/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.199
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