EXTH-57. PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF THE PROCASPASE-ACTIVATING COMPOUND, PAC-1, FOLLOWING ORAL ADMINISTRATION IN A NON-HUMAN PRIMATE MODEL

BACKGROUND: PAC-1 is a novel compound which induces apoptosis via activation of the procaspase-3 pathway in cancer cells. Human clinical trials are ongoing with PAC-1 as a single agent (late-stage cancers) and in combination therapies (malignant glioma), in addition to studies in pet canines (glioma...

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Publicado no:Neuro Oncol
Main Authors: McCully, Cynthia Lester, Cruz, Rafael, Lyubimov, Alexander V, Zakharov, Alexander D, Fischer, James H, Hergenrother, Paul J, Warren, Katherine E
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217255/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.405
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