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CADD-57. THE EFFICACY OF THERAPY WITH ABT-414, AN EGFR-TARGETING ADC, IS POTENTIALLY ALTERED BY HETEROZYGOUS DELETION OF THE ENDOCYTIC TRAFFICKING REGULATOR RBSN

Therapy with ABT-414 (depatux-m), a humanized monoclonal antibody drug conjugate (ADC) directed toward EGFRvIII and activated wild-type EGFR linked to MMAF, has demonstrated promising clinical activity in glioblastoma (GBM) patients with amplified EGFR and is currently being evaluated in clinical tr...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Muller-Greven, Gaelle, Marin, Bianca-Maria, Carlin, Cathleen, Reilly, Edward, Lee, Jeongwu, Bredel, Marcus, Sarkaria, Jann, Gladson, Candece
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216917/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1182
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