CADD-49. IDENTIFICATION AND VALIDATION OF AZOLES AS HK2 INHIBITORS IN GLIOBLASTOMA IN VITRO AND IN VIVO

BACKGROUND: Hexokinase I and 2 (HK1/HK2) catalyze the first committed step in glucose metabolism, ensuring a sustained glucose concentration gradient. Glioblastomas (GBMs) over-express HK2, and we have previously shown that its loss sensitizes GBM cells to treatment. In this study, we have conducted...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Agnihotri, Sameer, Mansouri, Sheila, Burrell, Kelly, Li, Mira, Liu, Jeff, Nejad, Romina, Kumar, Sushil, Jalali, Shahrzad, Singh, Sanjay, Vartanian, Alenoush, Xueyu Chen, Eric, Bunda, Severa, Mansouri, Alireza, Aldape, Kenneth, Zadeh, Gelareh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216877/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1177
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