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TM-02 IDENTIFICATION OF THE AZOLE CLASS OF ANTIFUNGALS AS POTENT INHIBITORS OF HEXOKINASE II MEDIATED TUMOUR METABOLISM IN GLIOBLASTOMA

Rapidly proliferating tumour cells preferentially use aerobic glycolysis over oxidative phosphorylation (OXPHOS) to support growth and survive unfavorable microenvironment conditions. This metabolic reprogramming is referred to as the “Warburg effect” and offers a novel way to target cancer cells in...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Agnihotri, Sameer, Vartanian, Alenoush, Burrell, Kelly, Singh, Sanjay, Alamsahebpour, Amir, Aldape, Kenneth, Zadeh, Gelareh
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218626/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou278.2
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