TM-02 IDENTIFICATION OF THE AZOLE CLASS OF ANTIFUNGALS AS POTENT INHIBITORS OF HEXOKINASE II MEDIATED TUMOUR METABOLISM IN GLIOBLASTOMA

Rapidly proliferating tumour cells preferentially use aerobic glycolysis over oxidative phosphorylation (OXPHOS) to support growth and survive unfavorable microenvironment conditions. This metabolic reprogramming is referred to as the “Warburg effect” and offers a novel way to target cancer cells in...

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I publikationen:Neuro Oncol
Huvudupphovsmän: Agnihotri, Sameer, Vartanian, Alenoush, Burrell, Kelly, Singh, Sanjay, Alamsahebpour, Amir, Aldape, Kenneth, Zadeh, Gelareh
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218626/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou278.2
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