CSIG-43. THE TYROSINE PHOSPHATASE PTPN12/PTP-PEST REGULATES PHOSPHORYLATION-DEPENDENT UBIQUITINATION AND STABILITY OF FOCAL ADHESION SUBSTRATES IN INVASIVE GLIOBLASTOMA CELLS

Glioblastoma (GBM) is an invasive brain cancer with tumor cells that disperse from the primary mass escaping surgical resection, displaying resistance to chemotherapy and radiation, and invariably giving rise to lethal recurrent lesions. Targeted therapies such as the anti-vascular endothelial growt...

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Publié dans:Neuro Oncol
Auteurs principaux: McCarty, Joseph, Morales, John, Guerrero, Paola, Chen, Zhihua
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216807/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.209
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