PATH-33. HEXOKINASE 2 KNOCKOUT VIA CRISPR REDUCES DOWNSTREAM GENE EXPRESSION, IMPLICATING A REDUCTION IN CELL PROLIFERATION AND DRUG RESISTANCE

HK2 has a prominent role in aerobic glycolysis and has been implicated in many cancer types including GBM, with overexpression associated with drug resistant phenotypes. Previously, we have demonstrated HK2 expression was upregulated between 6 to >1000 fold in GBM biopsy tissue (n=100) and patien...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Blakeway, Daniel, Karakoula, Katherine, Morris, Mark, Rowther, Farjana, Ashton, Kate, Dawson, Tim, Darling, John, Warr, Tracy
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Abstracts
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216765/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.689
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares