PATH-33. HEXOKINASE 2 KNOCKOUT VIA CRISPR REDUCES DOWNSTREAM GENE EXPRESSION, IMPLICATING A REDUCTION IN CELL PROLIFERATION AND DRUG RESISTANCE

HK2 has a prominent role in aerobic glycolysis and has been implicated in many cancer types including GBM, with overexpression associated with drug resistant phenotypes. Previously, we have demonstrated HK2 expression was upregulated between 6 to >1000 fold in GBM biopsy tissue (n=100) and patien...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Blakeway, Daniel, Karakoula, Katherine, Morris, Mark, Rowther, Farjana, Ashton, Kate, Dawson, Tim, Darling, John, Warr, Tracy
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216765/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.689
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