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Overexpression of Hexokinase 2 is epigenetically regulated by frequent hypomethylation in glioblastoma multiforme

HK2 has a prominent role in glycolysis, acting as the rate-limiting step in the pathway. HK2 is highly expressed in many cancers, with overexpression associated with drug resistant phenotypes. In parallel, its inhibition has improved the effectiveness of anticancer agents. Evidence indicates that HK...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Blakeway, Daniel, Karakoula, Katherine, Morris, Mark, Rowther, Farjana, Eagles, Lawrence, Darling, John, Warr, Tracy
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791708/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox238.053
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