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Overexpression of Hexokinase 2 is epigenetically regulated by frequent hypomethylation in glioblastoma multiforme
HK2 has a prominent role in glycolysis, acting as the rate-limiting step in the pathway. HK2 is highly expressed in many cancers, with overexpression associated with drug resistant phenotypes. In parallel, its inhibition has improved the effectiveness of anticancer agents. Evidence indicates that HK...
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| Published in: | Neuro Oncol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5791708/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox238.053 |
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