DDIS-22. WSD0922: A BBB PENETRABLE EGFR/EGFRVIII SMALL MOLECULE FOR THE TREATMENT OF GBM AND METASTATIC CNS TUMOR

Aberrant EGFR signaling caused by mechanisms of overexpression, mutation, or autocrine activation contributes for oncogenesis by inducing cell proliferation and resisting apoptosis. In patients with GBM, an overall frequency of 25–64% mutation is EGFRvIII (exon2-7 deletion). In patients with NSCLC h...

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Published in:Neuro Oncol
Main Authors: Zhong, Wei, Zhang, Jinqiang, Mu, Zhihua, Sun, Claire
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216298/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.301
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