DDIS-22. WSD0922: A BBB PENETRABLE EGFR/EGFRVIII SMALL MOLECULE FOR THE TREATMENT OF GBM AND METASTATIC CNS TUMOR

Aberrant EGFR signaling caused by mechanisms of overexpression, mutation, or autocrine activation contributes for oncogenesis by inducing cell proliferation and resisting apoptosis. In patients with GBM, an overall frequency of 25–64% mutation is EGFRvIII (exon2-7 deletion). In patients with NSCLC h...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Zhong, Wei, Zhang, Jinqiang, Mu, Zhihua, Sun, Claire
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2018
Konular:
Abstracts
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216298/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.301
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