ACTR-22. A PHASE I STUDY OF CYTOSINE DEAMINASE-EXPRESSING NEURAL STEM CELLS (CD-NSCs) ADMINISTERED INTRACRANIALLY AND IN COMBINATION WITH ORAL 5-FLUOROCYTOSINE (5-FC) AND LEUCOVORIN IN PATIENTS WITH RECURRENT HIGH GRADE GLIOMA

BACKGROUND: Human NSCs are tumor tropic, making them attractive vehicles for delivery of therapeutics. An immortalized, clonal NSC line was retrovirally transduced to express CD, which converts 5-FC to 5-fluorouracil (5-FU). The primary objectives of this study were to assess the feasibility of seri...

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Publicado en:Neuro Oncol
Main Authors: Portnow, Jana, Synold, Timothy, Badie, Behnam, Blanchard, Suzette, Kilpatrick, Julie, Tirughana, Revathiswari, Metz, Marianne, Tran, Vivi, Aboody, Karen
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216182/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.056
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