The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study

Rodent studies indicate that ghrelin receptor blockade reduces alcohol consumption. However, no ghrelin receptor blockers have been administered to heavy drinking individuals. Therefore, we evaluated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and behavioral effects of a n...

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Xehetasun bibliografikoak
Argitaratua izan da:Mol Psychiatry
Egile Nagusiak: Lee, Mary R., Tapocik, Jenica D., Ghareeb, Mwlod, Schwandt, Melanie L., Dias, Alexandra A., Le, April N., Cobbina, Enoch, Farinelli, Lisa A., Bouhlal, Sofia, Farokhnia, Mehdi, Heilig, Markus, Akhlaghi, Fatemeh, Leggio, Lorenzo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215751/
https://ncbi.nlm.nih.gov/pubmed/29728704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0064-y
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