The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study

Rodent studies indicate that ghrelin receptor blockade reduces alcohol consumption. However, no ghrelin receptor blockers have been administered to heavy drinking individuals. Therefore, we evaluated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and behavioral effects of a n...

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Pubblicato in:Mol Psychiatry
Autori principali: Lee, Mary R., Tapocik, Jenica D., Ghareeb, Mwlod, Schwandt, Melanie L., Dias, Alexandra A., Le, April N., Cobbina, Enoch, Farinelli, Lisa A., Bouhlal, Sofia, Farokhnia, Mehdi, Heilig, Markus, Akhlaghi, Fatemeh, Leggio, Lorenzo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215751/
https://ncbi.nlm.nih.gov/pubmed/29728704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0064-y
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