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Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach

(R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)ethan-1-one (PF-5190457) was identified as a potent and selective inverse agonist of the ghrelin receptor [growth hormone secretagogue receptor 1a (GHS-R1a)]. The pres...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Adusumalli, Sravani, Jamwal, Rohitash, Obach, R. Scott, Ryder, Tim F., Leggio, Lorenzo, Akhlaghi, Fatemeh
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636241/
https://ncbi.nlm.nih.gov/pubmed/31182423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.087015
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