Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance

Many patients remain unresponsive to intensive PD-1/PD-L1 blockade therapy despite the presence of tumor-infiltrating lymphocytes. We propose that impaired innate sensing might limit the complete activation of tumor-specific T cells after PD-1/PD-L1 blockade. Local delivery of type I interferons (IF...

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Udgivet i:Nat Commun
Main Authors: Liang, Yong, Tang, Haidong, Guo, Jingya, Qiu, Xiangyan, Yang, Zecheng, Ren, Zhenhua, Sun, Zhichen, Bian, Yingjie, Xu, Lily, Xu, Hairong, Shen, Jiao, Han, Yanfei, Dong, Haidong, Peng, Hua, Fu, Yang-Xin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214895/
https://ncbi.nlm.nih.gov/pubmed/30389912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06890-y
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