Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer

Although smoking is a significant risk factor for pancreatic cancer (PDAC), the molecular mechanisms underlying PDAC development and progression in smokers are still unclear. Here we show the role of cAMP response element-binding protein (CREB) in the pathogenesis of smoking-induced PDAC. Smokers ha...

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Udgivet i:Cancer Res
Main Authors: Srinivasan, Supriya, Totiger, Tulasigeri, Shi, Chanjuan, Castellanos, Jason, Lamichhane, Purushottam, Dosch, Austin R., Messaggio, Fanuel, Kashikar, Nilesh, Honnenahally, Kumaraswamy, Ban, Yuguang, Merchant, Nipun B., VanSaun, Michael, Nagathihalli, Nagaraj S.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214726/
https://ncbi.nlm.nih.gov/pubmed/30232221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0579
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