CREB Drives Acinar to Ductal Cells Reprogramming and Promotes Pancreatic Cancer Progression in Preclinical Models of Alcoholic PancreatitisSummary

Background & Aims: Chronic alcoholism often leads to pancreatitis, which exacerbates pancreatic damage through acinar cell injury and fibrotic inflammation activating AKT/mTOR/cyclic adenosine monophosphate response element binding protein 1 (CREB) signaling axis. However, the molecular inte...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Supriya Srinivasan, Siddharth Mehra, Sudhakar Jinka, Anna Bianchi, Samara Singh, Austin R. Dosch, Haleh Amirian, Varunkumar Krishnamoorthy, Iago De Castro Silva, Manan Patel, Edmond Worley III. Box, Vanessa Garrido, Tulasigeri M. Totiger, Zhiqun Zhou, Yuguang Ban, Jashodeep Datta, Michael VanSaun, Nipun Merchant, Nagaraj S. Nagathihalli
التنسيق: Artigo
اللغة:Inglês
منشور في: Elsevier 2025-01-01
سلاسل:Cellular and Molecular Gastroenterology and Hepatology
الموضوعات:
Acinar-To-Ductal Metaplasia
Alcoholic Chronic Pancreatitis
cAMP Response Element Binding Protein 1
Pancreatic Cancer
Pancreatic Ductal Adenocarcinoma
Pancreatic Intraepithelial Neoplasia
الوصول للمادة أونلاين:http://www.sciencedirect.com/science/article/pii/S2352345X2500147X
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