Transfusion of platelets loaded with recombinant ADAMTS13 is efficacious for inhibiting arterial thrombosis in mice and in human

OBJECTIVE: ADAMTS13 cleaves von Willebrand factor (VWF). This process is essential for hemostasis. Severe deficiency of plasma ADAMTS13 activity, most commonly resulting from autoantibodies against ADAMTS13, causes thrombotic thrombocytopenic purpura (TTP). Therapeutic plasma exchange is the standar...

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Détails bibliographiques
Publié dans:Arterioscler Thromb Vasc Biol
Auteurs principaux: Abdelgawwad, Mohammad S., Cao, Wenjing, Zheng, Liang, Kocher, Nicole K., Williams, Lance A., Long Zheng, X.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214616/
https://ncbi.nlm.nih.gov/pubmed/30354235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311407
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