Transfusion of platelets loaded with recombinant ADAMTS13 is efficacious for inhibiting arterial thrombosis in mice and in human

OBJECTIVE: ADAMTS13 cleaves von Willebrand factor (VWF). This process is essential for hemostasis. Severe deficiency of plasma ADAMTS13 activity, most commonly resulting from autoantibodies against ADAMTS13, causes thrombotic thrombocytopenic purpura (TTP). Therapeutic plasma exchange is the standar...

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Bibliografske podrobnosti
izdano v:Arterioscler Thromb Vasc Biol
Main Authors: Abdelgawwad, Mohammad S., Cao, Wenjing, Zheng, Liang, Kocher, Nicole K., Williams, Lance A., Long Zheng, X.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214616/
https://ncbi.nlm.nih.gov/pubmed/30354235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311407
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