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Transfusion of platelets loaded with recombinant ADAMTS13 is efficacious for inhibiting arterial thrombosis in mice and in human
OBJECTIVE: ADAMTS13 cleaves von Willebrand factor (VWF). This process is essential for hemostasis. Severe deficiency of plasma ADAMTS13 activity, most commonly resulting from autoantibodies against ADAMTS13, causes thrombotic thrombocytopenic purpura (TTP). Therapeutic plasma exchange is the standar...
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| Publicado no: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6214616/ https://ncbi.nlm.nih.gov/pubmed/30354235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311407 |
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