A Copper-Mediated Conjugate Addition Approach to Analogues of Aconitine-Type Diterpenoid Alkaloids

A copper-mediated conjugate addition of electron-rich aryl groups into a complex vinyl nitrile using arylmagnesium bromides is reported. The conjugate addition adducts were advanced toward the synthesis of designed aconitine-type analogues. The variation in oxygenation patterns on the arene coupling...

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Bibliographic Details
Published in:J Org Chem
Main Authors: Doering, Nicolle A., Kou, Kevin G. M., Norseeda, Krissada, Lee, Jack C., Marth, Christopher J., Gallego, Gary M., Sarpong, Richmond
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214151/
https://ncbi.nlm.nih.gov/pubmed/30216070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.8b01967
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