Dietary Sodium Restriction Reduces Arterial Stiffness, Vascular TGF-β-Dependent Fibrosis and Marinobufagenin in Young Normotensive Rats

High salt (HS) intake stimulates the production of marinobufagenin (MBG), an endogenous steroidal Na/K-ATPase ligand, which activates profibrotic signaling. HS is accompanied by a blood pressure (BP) increase in salt-sensitive hypertension, but not in normotensive animals. Here, we investigated whet...

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Pubblicato in:Int J Mol Sci
Autori principali: Grigorova, Yulia N., Wei, Wen, Petrashevskaya, Natalia, Zernetkina, Valentina, Juhasz, Ondrej, Fenner, Rachel, Gilbert, Christian, Lakatta, Edward G., Shapiro, Joseph I., Bagrov, Alexei Y., Fedorova, Olga V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214093/
https://ncbi.nlm.nih.gov/pubmed/30326586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19103168
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