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Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway
BACKGROUND: The bioactive steroid, marinobufagenin (MBG), is an endogenous Na/K-ATPase bufadienolide inhibitor that is synthetized by adrenocortical and placental cells. MBG binding to Na/K-ATPase initiates pro-fibrotic cell signaling, and heightened MBG levels are implicated in the pathogenesis of...
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| Publicado no: | Circ Cardiovasc Genet |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4618091/ https://ncbi.nlm.nih.gov/pubmed/26374826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.115.001217 |
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