Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway

BACKGROUND: The bioactive steroid, marinobufagenin (MBG), is an endogenous Na/K-ATPase bufadienolide inhibitor that is synthetized by adrenocortical and placental cells. MBG binding to Na/K-ATPase initiates pro-fibrotic cell signaling, and heightened MBG levels are implicated in the pathogenesis of...

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Detaylı Bibliyografya
Yayımlandı:Circ Cardiovasc Genet
Asıl Yazarlar: Fedorova, Olga V., Zernetkina, Valentina I., Shilova, Victoria Y., Grigorova, Yulia N., Juhasz, Ondrej, Wei, Wen, Marshall, Courtney A., Lakatta, Edward G., Bagrov, Alexei Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618091/
https://ncbi.nlm.nih.gov/pubmed/26374826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.115.001217
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