Marinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists

OBJECTIVE: Endogenous cardiotonic steroids (CTS), including marinobufagenin (MBG), stimulate vascular synthesis of collagen. Because mineralocorticoid antagonists competitively antagonize effect of CTS on the Na/K-ATPase, we hypothesized that spironolactone would reverse the pro-fibrotic effects of...

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Detaylı Bibliyografya
Yayımlandı:J Hypertens
Asıl Yazarlar: Fedorova, Olga V., Emelianov, Igor V., Bagrov, Konstantin A., Grigorova, Yulia N., Wei, Wen, Juhasz, Ondrej, Frolova, Elena V., Marshall, Courtney A., Lakatta, Edward G., Konradi, Alexandra O., Bagrov, Alexei Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547457/
https://ncbi.nlm.nih.gov/pubmed/26136067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0000000000000591
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