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Marinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists

OBJECTIVE: Endogenous cardiotonic steroids (CTS), including marinobufagenin (MBG), stimulate vascular synthesis of collagen. Because mineralocorticoid antagonists competitively antagonize effect of CTS on the Na/K-ATPase, we hypothesized that spironolactone would reverse the pro-fibrotic effects of...

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Detalhes bibliográficos
Publicado no:J Hypertens
Main Authors: Fedorova, Olga V., Emelianov, Igor V., Bagrov, Konstantin A., Grigorova, Yulia N., Wei, Wen, Juhasz, Ondrej, Frolova, Elena V., Marshall, Courtney A., Lakatta, Edward G., Konradi, Alexandra O., Bagrov, Alexei Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547457/
https://ncbi.nlm.nih.gov/pubmed/26136067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0000000000000591
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