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Marinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists
OBJECTIVE: Endogenous cardiotonic steroids (CTS), including marinobufagenin (MBG), stimulate vascular synthesis of collagen. Because mineralocorticoid antagonists competitively antagonize effect of CTS on the Na/K-ATPase, we hypothesized that spironolactone would reverse the pro-fibrotic effects of...
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| Pubblicato in: | J Hypertens |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4547457/ https://ncbi.nlm.nih.gov/pubmed/26136067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0000000000000591 |
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