Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, Is Reduced by a Monoclonal Antibody to Marinobufagenin

BACKGROUND: Marinobufagenin (MBG) is an endogenous Na/K-ATPase inhibitor, a natriuretic and a vasoconstrictor. MBG is implicated in salt-sensitive hypertension, cardiac hypertrophy, and initiate the pro-fibrotic signaling. Previously it was demonstrated that immunoneutralization of an endogenous MBG...

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Detalhes bibliográficos
Publicado no:Am J Hypertens
Main Authors: Grigorova, Yulia N., Juhasz, Ondrej, Zernetkina, Valentina, Fishbein, Kenneth W., Lakatta, Edward G., Fedorova, Olga V., Bagrov, Alexei Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014083/
https://ncbi.nlm.nih.gov/pubmed/26350300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ajh/hpv155
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