Monoclonal Antibody to Marinobufagenin Downregulates TGFβ Profibrotic Signaling in Left Ventricle and Kidney and Reduces Tissue Remodeling in Salt‐Sensitive Hypertension

BACKGROUND: Elevated levels of an endogenous Na/K‐ATPase inhibitor marinobufagenin accompany salt‐sensitive hypertension and are implicated in cardiac fibrosis. Immunoneutralization of marinobufagenin reduces blood pressure in Dahl salt‐sensitive (Dahl‐S) rats. The effect of the anti‐marinobufagenin...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Zhang, Yongqing, Wei, Wen, Shilova, Victoria, Petrashevskaya, Natalia N., Zernetkina, Valentina I., Grigorova, Yulia N., Marshall, Courtney A., Fenner, Rachel C., Lehrmann, Elin, Wood, William H., Becker, Kevin G., Lakatta, Edward G., Bagrov, Alexei Y., Fedorova, Olga V.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818028/
https://ncbi.nlm.nih.gov/pubmed/31576777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.012138
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