Efficacy Evaluation of Combination Treatment Using Gemcitabine and Radioimmunotherapy with (90)Y-Labeled Fully Human Anti-CD147 Monoclonal Antibody 059-053 in a BxPC-3 Xenograft Mouse Model of Refractory Pancreatic Cancer

The poor prognosis of pancreatic cancer requires the development of more effective therapy. CD147 expresses in pancreatic cancer with high incidence and has a crucial role in invasion and metastasis. We developed a fully human monoclonal antibody (059-053) with high affinity for CD147. Here we evalu...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Sugyo, Aya, Tsuji, Atsushi B., Sudo, Hitomi, Koizumi, Mitsuru, Ukai, Yoshinori, Kurosawa, Gene, Kurosawa, Yoshikazu, Saga, Tsuneo, Higashi, Tatsuya
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213240/
https://ncbi.nlm.nih.gov/pubmed/30274301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19102979
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